Original Research Original ResearchDoc head & section head both text are the same. please check|Articles in Press, 100928

Association of Chronic kidney dysfunction and preeclampsia: Insights of the Nationwide Inpatient Sample



      Preeclampsia occurs in 3-5% of pregnancies and can lead to potentially fatal outcomes for parent and child. Disparities in socio-economic status, medical access, racial/ethnical and regional background within the United States result in a very heterogenic population.


      We aimed to assess the regional differences in severity of chronic kidney disease in pregnant patients and risk of preeclampsia in a contemporary cohort within the United States.


      Pregnant patients were identified within the National Inpatient Sample database between 2015 and 2019. Patients were stratified by diagnosis of end stage kidney disease or chronic kidney disease. The primary endpoint of this study was to determine the incidence of mild preeclampsia, severe preeclampsia and eclampsia in hospitalized pregnant patients with kidney dysfunction compared to controls. Secondary endpoints were to determine regional, racial/ethnical and socio-economic differences within the United States.


      A total of 16,343,563 pregnant patients were identified within 2015-2019. Presence of chronic kidney disease increased risk of mild and severe preeclampsia independent of the stage of chronic kidney disease (Odds ratio >2 each). There was a significant difference in prevalence of chronic kidney disease in regard to geographic location within the United States, with patients in the Northeast having predominantly milder stages of chronic kidney disease and patients in the South and West having more progressive kidney disease. There was a significant difference in chronic kidney disease distribution in relation to racial/ethnical background within the United States. Black and Latinx patients were at increased risk of eclampsia and death. There was no significant difference regarding chronic kidney disease and socio-economic background. However, a larger proportion of patients with very low income had advanced stages of chronic kidney disease.


      Our data adds to the prior findings that patients with chronic kidney disease are at increased risk of developing preeclampsia even in the modern era of medical management, independent of the cause of chronic kidney disease. Racial/ethnical and geographical differences in chronic kidney disease prevalence exist. A multi-disciplinary team approach to follow pregnant patients with chronic kidney disease could decrease the maternal and neonatal mortality.


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