AJOG at a glance
- AWhy was this study conducted?
- •Although pregnant women at risk of eclampsia have been shown to benefit from aspirin, the potential bleeding risk of aspirin should not be ignored.
- •Studies of the association between aspirin and postpartum hemorrhage have been controversial.
- •A major limitation of the available meta-analyses is a lack of robust definition of postpartum hemorrhage in most studies cited, compared with which the amount of postpartum blood loss may be more reliable. However, no meta-analyses have focused on the association between aspirin use during pregnancy and the specific amount of postpartum blood loss.
- BWhat are the key findings?
- •Aspirin use during pregnancy is one possible reason for the increased risk of postpartum hemorrhage.
- •Aspirin use during pregnancy do slightly increase the amount of postpartum blood loss.
- •The conclusions are more likely to be obtained in developed countries.
- CWhat does this study add to what is already known?
- •This is the first study to explore the relationship between aspirin use during pregnancy and the amount of postpartum blood loss.
- •Without denying the combined value of aspirin, our conclusions raise alarm for clinicians to postpartum hemorrhage in women using aspirin during pregnancy.
Study Appraisal and Synthesis Methods
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Publication stageIn Press Accepted Manuscript
Conflict of interest: The authors report no conflict of interest.
Funding: This work was supported by the Nation Key Research and Development Program of China (2021YFC2701502)
Paper presentations: This paper has not been presented at any meetings
Condensation: Aspirin use during pregnancy may increase the risk of postpartum hemorrhage and the amount of postpartum blood loss.