- AWhy was the study conducted? To evaluate whether a composite of neonatal mortality and short-term morbidity increases as maternal BMI at delivery increases.
- BWhat are the key findings?
- -Maternal comorbidities, including chronic hypertension, pre-gestational diabetes, and cesarean delivery are more frequent in higher BMI categories.
- -Compared with the reference group (BMI 18.5-29.9 kg/m2), only neonates born to pregnant people with a BMI of 40-49.9 kg/m2 were at increased risk for composite morbidity.
- CWhat does this study add to what is already known? After adjusting for other comorbidities, such as chronic hypertension, diabetes, preeclampsia/eclampsia and preterm birth, increasing maternal BMI is not associated with an increase in composite neonatal morbidity.
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Publication stageIn Press Accepted Manuscript
Funding: The project described was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [HD21410, HD27869, HD27915, HD27917, HD34116, HD34208, U10 HD36801, HD40500, HD40512, HD40544, HD40545, HD40560, HD40485, HD53097, HD53118] and the National Center for Research Resources [UL1 RR024989; 5UL1 RR025764]. Comments and views of the authors do not necessarily represent views of the NIH.
Acknowledgments: The authors thank William A. Grobman, M.D., M.B.A., Elizabeth Thom, Ph.D., Madeline M. Rice, Ph.D., Brian M. Mercer, M.D. and Catherine Y. Spong, M.D. for protocol development and oversight.
Presented in part at the 38th annual meeting of the Society for Maternal-Fetal Medicine, January 29-February 3, 2018, Dallas, TX.
The authors have no conflicts of interest or financial disclosures.
In addition to the authors, other members of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network are as follows:
Northwestern University, Chicago, IL – W. Grobman, G. Mallett, M. Ramos-Brinson, A. Roy, L. Stein, P. Campbell, C. Collins, N. Jackson, J. Senka (NorthShore University HealthSystem), K. Paychek (NorthShore University HealthSystem), A. Peaceman
Columbia University, New York, NY – M. Talucci, M. Zylfijaj, Z. Reid (Drexel U.), R. Leed (Drexel U.), J. Benson (Christiana H.), S. Forester (Christiana H.), C. Kitto (Christiana H.), S. Davis (St. Peter's UH.), M. Falk (St. Peter's UH.), C. Perez (St. Peter's UH)
University of Utah Health Sciences Center, Salt Lake City, UT – K. Hill, A. Sowles, J. Postma (LDS Hospital), S. Alexander (LDS Hospital), G. Andersen (LDS Hospital), V. Scott (McKay-Dee), V. Morby (McKay-Dee), K. Jolley (UVRMC), J. Miller (UVRMC), B. Berg (UVRMC)
University of North Carolina at Chapel Hill, Chapel Hill, NC – K. Dorman, J. Mitchell, E. Kaluta, K. Clark (WakeMed), K. Spicer (WakeMed), S. Timlin (Rex), K. Wilson (Rex)
University of Texas Southwestern Medical Center, Dallas, TX – L. Moseley, K. Leveno (deceased), M. Santillan, J. Price, K. Buentipo, V. Bludau, T. Thomas, L. Fay, C. Melton, J. Kingsbery, R. Benezue
University of Pittsburgh, Pittsburgh, PA – H. Simhan, M. Bickus, D. Fischer, T. Kamon (deceased), D. DeAngelis
MetroHealth Medical Center-Case Western Reserve University, Cleveland, OH – B. Mercer, C. Milluzzi, W. Dalton, T. Dotson, P. McDonald, C. Brezine, A. McGrail
The Ohio State University, Columbus, OH – C. Latimer, L. Guzzo (St. Ann's), F. Johnson, L. Gerwig (St. Ann's), S. Fyffe, D. Loux (St. Ann's), S. Frantz, D. Cline, S. Wylie, J. Iams
University of Alabama at Birmingham, Birmingham, AL – M. Wallace, A. Northen, J. Grant, C. Colquitt, D. Rouse, W. Andrews
University of Texas Medical Branch, Galveston, TX – J. Moss, A. Salazar, A. Acosta, G. Hankins
Wayne State University, Detroit, MI – N. Hauff, L. Palmer, P. Lockhart, D. Driscoll, L. Wynn, C. Sudz, D. Dengate, C. Girard, S. Field
Brown University, Providence, RI – P. Breault, F. Smith, N. Annunziata, D. Allard, J. Silva, M. Gamage, J. Hunt, J. Tillinghast, N. Corcoran, M. Jimenez
The University of Texas Health Science Center at Houston, McGovern Medical School-Children's Memorial Hermann Hospital, Houston, TX– F. Ortiz, P. Givens, B. Rech, C. Moran, M. Hutchinson, Z. Spears, C. Carreno, B. Heaps, G. Zamora
Oregon Health & Science University, Portland, OR – J. Seguin, M. Rincon, J. Snyder, C. Farrar, E. Lairson, C. Bonino, W. Smith (Kaiser Permanente), K. Beach (Kaiser Permanente), S. Van Dyke (Kaiser Permanente), S. Butcher (Kaiser Permanente)
The George Washington University Biostatistics Center, Washington, D.C. – E. Thom, M. Rice, Y. Zhao, V. Momirova, R. Palugod, B. Reamer, M. Larsen
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD – C. Spong, S. Tolivaisa
MFMU Network Steering Committee Chair (Medical University of South Carolina, Charleston, SC) – J. P. VanDorsten, M.D.
Condensation: Increasing maternal BMI is not associated with a progressive increase in composite neonatal morbidity.