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Prediction of hypertensive disorders of pregnancy using metabolomics: there is a long way to go

  • Bincy Varghese
    Affiliations
    Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research-Guwahati, Guwahati, Assam, India
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  • Roshan M Borkar
    Affiliations
    Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research-Guwahati, Guwahati, Assam, India
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  • Ramu Adela
    Correspondence
    Corresponding Author: Dr. Ramu Adela, Ph.D, Assistant Professor, Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research-Guwahati, Sila Katamur Village, Changsari, Assam-781101 Contact No. +91-8860280242
    Affiliations
    Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research-Guwahati, Sila Katamur Village, Changsari, Assam
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Published:January 19, 2023DOI:https://doi.org/10.1016/j.ajogmf.2023.100866
      We thank the editors for the opportunity to respond to the commentary written by Li et al., 2022, in response to our recent publication [1]. We also thank Li et al. for their interest in our work and would like to note their additional commentary. The commentary raises questions: Were any differences found between the hypertensive disorder of pregnancy patients with and without proteinuria? Another limitation is that there were no non-pregnant women as controls. What are the background urine metabolite signatures in women? Are there any differences between the two groups? How are they changed when pregnancy occurs? Do they have the same change patterns for the two groups?  We have addressed them below:
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