Hypertensive disorders of pregnancy (HDP) are the most common medical complication
of pregnancy, affecting approximately 10% of pregnancies.
1
They are still a leading cause of maternal and perinatal mortality worldwide. As
a consequence, antenatal care is devoted in large part to their detection and prediction.
The risk factors for HDP are related to clinical epidemiologic, hemodynamic, and basic
biochemical factors. For example, combining clinical maternal risk markers, placental
growth factor, and uterine artery pulsatility index in the first trimester of pregnancy
has sensitivities of 75% for preterm preeclampsia and 47% for term preeclampsia, whereas
the use of clinical risk markers alone has sensitivities of 34% for preterm preeclampsia
and 39% for term preeclampsia.
2
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References
- Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy.Am J Obstet Gynecol. 2000; 183: S1-22
- Guideline No. 426: hypertensive disorders of pregnancy: diagnosis, prediction, prevention, and management.J Obstet Gynaecol Can. 2022; 44 (e1): 547-571
- Integrated metabolomics and machine learning approach to predict hypertensive disorders of pregnancy.Am J Obstet Gynecol MFM. 2022; 5100829
- Prediction of pregnancy-related hypertensive disorders using metabolomics: a systematic review.BMJ Open. 2022; 12e054697
Article info
Publication history
Published online: January 20, 2023
Accepted:
December 15,
2022
Received:
December 4,
2022
Footnotes
The authors report no conflict of interest.
Identification
Copyright
© 2023 Elsevier Inc. All rights reserved.
