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Pregnancy outcomes following early fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome at 16 weeks’ gestation

  • Rachel D. Seaman
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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  • Bahram Salmanian
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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  • Alireza A. Shamshirsaz
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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  • Jimmy Espinoza
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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  • Magdalena Sanz-Cortes
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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  • Roopali Donepudi
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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  • Rebecca Johnson
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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  • Eyal Krispin
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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  • Raphael Sun
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)

    Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX (Drs Sun and Belfort)
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  • Michael A. Belfort
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)

    Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX (Drs Sun and Belfort)
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  • Ahmed A. Nassr
    Correspondence
    Corresponding author:
    Affiliations
    Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital Pavilion for Women, Houston, TX (Drs Seaman, Salmanian, Shamshirsaz, Espinoza, Sanz-Cortes, and Donepudi, Ms Johnson, and Drs Krispin, Sun, Belfort, and Nassr)
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Published:October 13, 2022DOI:https://doi.org/10.1016/j.ajogmf.2022.100771

      BACKGROUND

      Ample evidence supports fetoscopic laser photocoagulation of placental anastomoses as a first-line treatment for twin-to-twin transfusion syndrome, but little is known about the outcomes following procedures conducted in the early second trimester.

      OBJECTIVE

      This study aimed to evaluate perinatal outcomes following early fetoscopic laser placental photocoagulation performed for twin-to-twin transfusion syndrome at 16 weeks’ gestation.

      STUDY DESIGN

      This retrospective review included monochorionic twin pregnancies complicated by twin-to-twin transfusion syndrome necessitating fetoscopic laser photocoagulation at a single tertiary center from 2012 to 2021. The 2 cohorts were defined as cases undergoing laser surgery at 16+0/7 to 16+6/7 weeks’ gestation (early laser group) and those undergoing laser surgery ≥17 weeks’ gestation (standard laser group), respectively. Primary outcomes included rates of immediate chorioamniotic membrane separation, preterm premature rupture of membranes, and clinical chorioamnionitis. Secondary outcomes included twin survival rates at birth and 30 days of life. Outcomes were compared between cohorts with a P value of <.05 denoting statistical significance.

      RESULTS

      A total of 343 cases were included (35 early laser participants and 308 standard laser participants). The early laser group typically had higher Quintero staging at the time of the procedure. Following intervention, the early laser group had significantly higher rates of chorioamniotic separation than the standard laser group (34.3% vs 1.3% of cases; P<.001) and higher rates of preterm prelabor rupture of membranes (45.7% vs 25.0%; P=.009) and chorioamnionitis (11.4% vs 1.3%; P=.005). Even after adjustment for higher Quintero staging in the early laser group, twin survival was not significantly different between study groups.

      CONCLUSION

      Early laser surgery for twin-to-twin transfusion syndrome performed at 16 weeks’ gestation is associated with significantly higher rates of chorioamniotic separation, preterm rupture of membranes, and chorioamnionitis. However, twin survival does not seem to be negatively impacted following early laser surgery.

      Keywords

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